Data reveals higher global burden of tuberculosis

Geneva:  Recent intensive efforts to improve collection and reporting of data on tuberculosis are shedding new light on the epidemic, revealing that there are almost half a million more cases of the disease than previously estimated. The World Health Organization’s Global Tuberculosis Report 2014 shows that 9 million people developed TB in 2013, and 1.5 million died, including 360 000 people who were HIV positive.

The report stresses, however, that the mortality rate from TB is still falling and has dropped by 45% since 1990, while the number of people developing the disease is declining by an average 1.5% a year. An estimated 37 million lives have been saved through effective diagnosis and treatment of TB since 2000.

The report underlines that a staggering number of lives are being lost to a curable disease and confirms that TB is the second biggest killer disease from a single infectious agent. In addition, around 3 million people who fall ill from TB are still being ‘missed’ by health systems each year either because they are not diagnosed, or because they are diagnosed but not reported.

Insufficient funding is hampering efforts to combat the global epidemic. An estimated US$ 8 billion is needed each year for a full response, but there is currently an annual shortfall of US$ 2 billion.
Diagnostic capacity for MDR-TB increasing faster than treatment capacity

The multidrug resistant TB (MDR-TB) crisis continues, with an estimated 480 000 new cases in 2013. Worldwide, about 3.5% of all people who developed TB in 2013 had this form of the disease, which is much harder to treat and has significantly poorer cure rates. While the estimated percentage of new TB cases that have MDR-TB globally remains unchanged, there are severe epidemics in some regions, particularly in Eastern Europe and Central Asia. Furthermore, extensively drug-resistant TB (XDR-TB), which is even more expensive and difficult to treat than MDR-TB, has now been reported in 100 countries.

In 2013, 136 000 MDR-TB cases were detected and 97 000 people were started on treatment. Although the number of patients treated has increased three-fold since 2009, at least 39 000 patients, diagnosed with this form of TB, were not being treated last year and globally only 48% of patients were cured.
A special supplement to this year’s WHO report marks 20 years of anti-TB drug-resistance surveillance. Anti-TB drug-resistance surveillance has been a pathfinder in global efforts against antimicrobial resistance (AMR).

HIV-related TB deaths down by one third in last decade

Another key challenge is the co-epidemic of TB and HIV.  An estimated 1.1 million (13%) of the 9 million people who developed TB in 2013 were HIV-positive, with 4 out of 5 cases and deaths occurring in the African Region.

While the number of TB deaths among HIV-positive people has been falling for almost a decade, from 540 000 in 2004 to 360 000 in 2013, antiretroviral treatment, preventive therapy and other key interventions still need to be further scaled-up.

Research funding urgently required

The research and development pipeline has produced several new diagnostics (such as Xpert MTB/RIF) and two new drugs to treat MDR-TB (bedaquiline and delamanid). Additional rapid tests, new drugs and drug regimens, and vaccines are in clinical trials. However, TB research and development is still severely underfunded.