Can drinking ketones improve heart health? What experts say about the latest study

A groundbreaking study suggests that drinking ketones before exercise may enhance heart function in individuals with type 2 diabetes. The research, conducted by the University of Portsmouth, found that participants who ingested ketone monoesters experienced improved cardiac output, stroke volume, and muscle oxygenation—key indicators of better heart health.

The Link Between Type 2 Diabetes and Heart Health

Type 2 diabetes affects millions worldwide and occurs when the body becomes resistant to insulin, leading to high blood glucose levels. Uncontrolled blood sugar can increase the risk of cardiovascular disease, making heart health a major concern for those with diabetes.

Common treatments for type 2 diabetes focus on reducing blood sugar levels. One such treatment—sodium-glucose cotransporter-2 inhibitors (SGLT2is)—has also been shown to protect heart health by promoting ketosis, a metabolic state where the body burns fat for energy instead of carbohydrates.

How the Study Was Conducted

To test whether ketosis itself benefits heart health, researchers enrolled 13 adults with type 2 diabetes in a controlled study. Each participant was given either a ketone monoester drink or a placebo before performing moderate exercise. Using thoracic impedance cardiography, scientists measured cardiac output, stroke volume, and peripheral muscle oxygenation.

Key Findings: How Ketones Affect the Heart

The study revealed that participants who consumed ketones showed notable improvements in heart function both at rest and during exercise. Their bodies produced higher levels of β-hydroxybutyrate—a key ketone body that carries energy from the liver to cells. This resulted in increased cardiac output and stroke volume, indicating more efficient heart performance.

Dr. Maria Perissiou, lead researcher at the University of Portsmouth, emphasized the significance of these findings:

“The hearts of all 13 participants worked more efficiently after consuming the ketone drink. This suggests that ketones have the potential to be an adjunct treatment for improving cardiac function and quality of life in people with type 2 diabetes. However, larger and long-term studies are needed.”

What Experts Say About Ketones and Heart Health

While promising, the study’s small sample size means further research is necessary to confirm long-term benefits. Dr. Cheng-Han Chen, a board-certified interventional cardiologist, commented:

“This was a small study that showed significant differences in heart function after ketone consumption. However, the methods used to measure cardiac function are not commonly applied in clinical settings.”

Meanwhile, Dr. Menka Gupta, a functional medicine expert, highlighted the possible mechanism behind ketones’ heart benefits:

“Exogenous ketones provide a highly efficient fuel source, producing more ATP per oxygen molecule than glucose. They may also reduce oxidative stress and inflammation, helping protect cardiac tissue.”

Should You Take Ketone Supplements?

Although the study suggests potential heart benefits, researchers caution against widespread ketone supplement use without further validation. High doses could cause stomach discomfort, electrolyte imbalances, or excessive ketone levels (ketonemia), particularly in people with diabetes.

The research team is now exploring how chronic ketone consumption might mitigate cardiovascular risks, particularly during heat waves. Dr. Perissiou noted that future studies will also examine whether similar benefits extend to non-diabetic populations.

For now, individuals considering ketone supplements should consult a healthcare provider to determine if they are a suitable option for their specific health conditions.